Development of the definition of sepsis

Sepsis is a significant health problem, considering that, annually, over 20 million people fall ill from sepsis. Despite the development of medicine in recent decades, mortality rate sepsis exceptionally high (about 26%). The definition developed together with understanding mechanism At beginning 1990s, first was created, according to which defined as systemic inflammatory response syndrome (SIRS), presence suspicion or evidence infection. Due many inadequately diagnosed patients sepsis, another clinical syndrome. As result lack clarity previous definitions and new information on pathophysiological process third 2016. According this definition, life-threatening condition based organic dysfunction resulting body's inappropriate Septic shock manifests circulatory, cellular metabolic instability. It characterized by serum lactate level higher than 2 mmol/l hypotension, requires vasopressor therapy after administration intravenous solutions. This septic enables early recognition treatment are critical steps reducing incidence disease.